Granulocytic sarcoma (chloroma). Case report

Main Article Content

Juan Rojas
María Álvarez
Diana Vanessa Suárez

Abstract

DOI: 10.1016/j.rcpe.2016.01.001


Background


The granulocytic sarcoma (SG) or chloroma is a solid tumour consisting of granulocyte precursor cells formed in an extramedullary location. It occurs in between 3% to 9% of patients with acute myeloid leukaemia (AML), and affecting mainly children under 15 years old.


Case summary


The case is presented of an 11 year-old girl with 8 months of inflammatory type pain in the left leg and hip, which increased with rest. On the 15 day of admission she had a rapidly progressive unilateral proptosis, which was diagnosed as a granulocytic sarcoma.


Conclusion


Although it is a rare tumour, early identification of SG is very important given the good response to radiotherapy and systemic chemotherapy


 

Downloads

Download data is not yet available.

Article Details

How to Cite
Rojas, J., Álvarez, M., & Suárez, D. V. (2016). Granulocytic sarcoma (chloroma). Case report. Pediatría, 49(1), 36–39. Retrieved from https://revistapediatria.org/rp/article/view/31
Section
Case report

References

1 A. Guermazi,C. Feger,P. Rousselot,M. Merad,N. Benchaib,P. Bourrier
Granulocytic sarcoma (chloroma): imaging findings in adults and children
AJR Am J Roentgenol., 178 (2002), pp. 319-325 http://dx.doi.org/10.2214/ajr.178.2.1780319
Medline

2 J. Shields,G. Stopyra,B. Marr,C. Shields
Bilateral Orbital Myeloid Sarcoma as Initial Sign of Acute Myeloid Leukemia: Case Report and Review of the Literature
Arch Ophthalmol, 121 (2003), pp. 138-142
Medline

3 B.W. Noh,S.-W. Park,J.-E. Chun,J.H. Kim,H.J. Kim,M.K. Lim
Granulocytic Sarcoma in the Head and Neck: CT and MR Imaging Findings
Clinical and Experimental Otorhinolaryngology., 2 (2009), pp. 66-71 http://dx.doi.org/10.3342/ceo.2009.2.2.66
Medline

4 M.H. Pui,B.D. Fletcher,J.W. Langston
Granulocytic sarcoma in childhood leukimia: imaging features
Radiology, 190 (1994), pp. 698-702 http://dx.doi.org/10.1148/radiology.190.3.8115614
Medline

5 A.F. Yilmaz,G. Saydam,F. Sahin,Y. Baran
Granulocytic sarcoma: a systematic review
American Journal of Blood Research., 3 (2013), pp. 265-270
Medline

6 A. Sethi,S. Ghose,S. Gujral,P. Jain,R. Kumar
Childhood proptosis: The invaluable, though often overlooked peripheral blood smear
Indian J Ophthalmol, 49 (2001), pp. 121-123
Medline

7 G.C. Ooi,C.S. Chim,P.L. Khong,W.Y. Au,A.K. Lie,K.W. Tsang
Radiologic manifestations of granulocytic sarcoma in adult leukemia
AJR Am J Roentgenol., 176 (2001 Jun), pp. 1427-1431 http://dx.doi.org/10.2214/ajr.176.6.1761427
Medline

8 Y.H. Lee,N.J. Lee,E.J. Choi,J.H. Kim
Granulocytic sarcoma (chloroma) presenting as a lateral neck mass: initial manifestation of leukemia: a case report
Eur Arch Otorhinolaryngol., 263 (2006 Jan), pp. 16-18 http://dx.doi.org/10.1007/s00405-005-0952-z
Medline

9 D.R. Nayak,R. Balakrishnan,G. Raj,S. Pillai,L. Rao,C. Manohar
locytic sarcoma of the head and neck: a case report
Am J Otolaryngol, 22 (2001), pp. 80-83 http://dx.doi.org/10.1053/ajot.2001.20692
Medline

10 J.L. Davis,D.W. 2nd Parke,R.L. Font
Granulocytic sarcoma of the orbit. A clinicopathologic study
Ophthamol, 92 (1985), pp. 1758-1762

11 L.E. Zimmerman,R.L. Font
Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma): the third Pan American Association of Ophthalmology and American Journal of Ophthalmology Lecture
Am J Ophthalmol, 80 (1975), pp. 975-990
Medline

12 P. Isik,B. Tavil,B. Tunç,N. Yarali,A. Demir,M. Cetin
Extramedullary orbital granulocytic sarcoma without bone marrow involvement: a report of two cases
Pediatr Hematol Oncol., 28 (2011), pp. 65-70 http://dx.doi.org/10.3109/08880018.2010.511439
Artículo | Medline

13 P. Mandal,T. Dolai
Early diagnosis and prompt therapy can save one's eye
Clin Cancer Investig J., 4 (2015), pp. 243-245

14 J. Zhou,D. Bell,L.J. Medeiros
Myeloid Sarcoma of the Head and Neck Region
Arch Pathol Lab Med., 137 (2013), pp. 1560-1568 http://dx.doi.org/10.5858/arpa.2012-0537-OA
Medline

15 A. Guermazi,C. Feger,P. Rousselot,M. Merad,N. Benchaib,P. Bourrier
Granulocytic sarcoma (chloroma): imaging findings in adults and children
AJR Am J Roentgenol., 178 (2002), pp. 319-325 http://dx.doi.org/10.2214/ajr.178.2.1780319
Medline

16 E. Aggarwal,K. Mulay
Honavar SG- Orbital extra-medullary granulocytic sarcoma: clinicopathologic correlation with immunohistochemical features
Surv Ophthalmol, 59 (2014), pp. 232-235 http://dx.doi.org/10.1016/j.survophthal.2013.06.004
Medline