Intravenous lipid emulsion therapy in acute poisoning in paediatric patients
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Abstract
DOI: 10.1016/j.rcpe.2016.08.001
After the discovery that intravenous lipid emulsion was an effective antidote for cardiotoxicity and neurotoxicity caused by local anaesthetics, further studies have been conducted to learn about its effectiveness in other poisonings with cardiotoxic effects.
The aim of this study was to identify publications concerning new drug groups. In addition, the selected publications have to include evidence obtained from paediatric patients. Lastly, the published indications were examined, along with the relevant evidence at the time.
Methods
PubMed and Science Direct were used to find relevant publications that include the terms: “fat emulsions”, “intravenous”, “poisoning”, “drug overdose”, “antidotes” and “paediatrics”. After having reviewed 452 articles, 439 were rejected because the abstracts had omitted the subject and/or paediatric patient. Consequently, 13 articles were included in this research.
Results
Published literature has been identified that show that intravenous lipid emulsion is effective in acute poisoning after the ingestion of tricyclic antidepressants, beta blockers, calcium channel blockers, bupropion, lamotrigine, quetiapine, sertraline, haloperidol, and zolpidem.
Conclusion
There is no evidence showing patient improvement as a consequence of administering intravenous lipid emulsion. However, there was a positive response in all cases where this treatment was administered.
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