Microbiota de la glándula mamaria
Barra lateral del artículo
Publicado:
jan. 1, 2015
Palabras clave:
Microbiota, Glándula mamaria, Lactancia materna, Lactobacillus reuteri DSM 17939, Bifidobacterium, longum, Lactobacillus fermentum CECT 5716, Inmunidad
Contenido principal del artículo
Resumen
DOI: 10.1016/j.rcpe.2015.07.001
Revisar y describir aspectos importantes de la literatura científica sobre la microbiota de la glándula mamaria. Se revisaron las bases de datos de revistas científicas.
En sus primeros días de vida, los recién nacidos son rápidamente colonizados por diferentes bacterias, a las que se les atribuye la iniciación de un poderoso sistema de defensa. Se cree que dichas bacterias garantizan un buen desarrollo físico e inmunológico.
La leche materna es uno de los factores que permite la colonización temprana, la cual confiere un sinnúmero de beneficios y tiene un impacto en la salud infantil y en la modulación de determinadas enfermedades a largo plazo.
La forma como las diferentes bacterias colonizan el intestino neonatal formando su propia microbiota, es debatida. Se asume que es multifactorial y que está influenciada por la vía del parto y la lactancia, que determinan una microbiota sana o una alterada de la cual se derivan diferentes enfermedades.
La microbiota de la glándula mamaria es única y son múltiples los factores que convergen para su conformación; con su adecuado establecimiento se generan factores protectores para la vida futura. La administración oral de probióticos derivados de la leche materna, abre la puerta para entender una nueva forma de colonización más eficiente de la microbiota del neonato. Lactobacillus reuteri DSM 17939, Bifidobacterium longum y Lactobacillus fermentum CECT 5716, fueron aislados de la leche materna de mujeres sanas y varios estudios confirman que pueden utilizarse en la nutrición humana.
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Cómo citar
Osorio, L. M., & Umbarila, A. S. (2015). Microbiota de la glándula mamaria. Pediatría, 48(1), 1–8. Recuperado a partir de https://revistapediatria.org/rp/article/view/44
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Citas
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Breast milk oligosaccharides: structure-function relationships in the neonate
Annu Rev Nutr, 34 (2014), pp. 143-169 http://dx.doi.org/10.1146/annurev-nutr-071813-105721
Medline
2 P.V. Jeurink,J. van Bergenhenegouwen,E. Jiménez,L.M. Knippels,L. Fernández,J. Garssen
Human milk: a source of more life than we imagine
Benef Microbes, 4 (2013), pp. 17-30 http://dx.doi.org/10.3920/BM2012.0040
Medline
3 C.L. Johnson,J. Versalovic
The human microbiome and its potential importance to pediatrics
Pediatrics, 129 (2012), pp. 950-960 http://dx.doi.org/10.1542/peds.2011-2736
Medline
4 R. Cabrera-Rubio,M.C. Collado,K. Laitinen,S. Salminen,E. Isolauri,A. Mira
The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery
Am J Clin Nutr, 96 (2012), pp. 544-551 http://dx.doi.org/10.3945/ajcn.112.037382
Medline
5 E. Jiménez,S. Langa,V. Martín,R. Arroyo,R. Martín,L. Fernández
Complete genome sequence of Lactobacillus fermentum CECT 5716, a probiotic strain isolated from human milk
J Bacteriol, 192 (2010), pp. 4800 http://dx.doi.org/10.1128/JB.00702-10
Medline
6 A. Marcobal,J.L. Sonnenburg
Human milk oligosaccharide consumption by intestinal microbiota
Clin Microbiol Infect, 18 (2012), pp. 12-15 http://dx.doi.org/10.1111/j.1469-0691.2012.03863.x
Medline
7 J.M. Rodriguez,E. Jimenez,V. Merino,A. Maldonado,M.L. Marin,L. Fernandez
Microbiota de la leche humana en condiciones fisiológicas
Acta Pediatr Esp, 66 (2008), pp. 77-82
8 D.S. Newburg,Innate Immunity,Milk. Human
American Society for Nutritional Sciences
Symposium by the American Society for Nutritional Sciences, (2005), pp. 1-5
9 N. León-Cava,C. Lutter,J. Ross,L. Martin
Quantifying the benefits of breastfeeding: a summary of the evidence Washington (DC): PAHO;, (2002),
10 K. Kukkonen,E. Savilahti,T. Haahtela,K. Juntunen-Backman,R. Korpela,T. Poussa
Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial
Pediatrics, 122 (2008), pp. 8-12 http://dx.doi.org/10.1542/peds.2007-1192
Medline
11 R. Martín,S. Langa,C. Reviriego,E. Jimenez,M. Marin,M. Olivares
The commensal microflora of human milk: new perspectives for food bacteriotherapy and probiotics
Trends Food Sci Technol, 15 (2004), pp. 121-127
12 T.M. Marques,R. Wall,R.P. Ross,G.F. Fitzgerald,C.A. Ryan,C. Stanton
Programming infant gut microbiota: influence of dietary and environmental factors
Curr Opin Biotechnol, 21 (2010), pp. 149-156 http://dx.doi.org/10.1016/j.copbio.2010.03.020
Medline
13 L. Bode
Human milk oligosaccharides: every baby needs a sugar mama
Glycobiology, 22 (2012), pp. 1147-1162 http://dx.doi.org/10.1093/glycob/cws074
Medline
14 D.W. Thomas,F.R. Greer
American Academy of Pediatrics Committee on Nutrition; American Academy of Pediatrics Section on Gastroenterology
Hepatology, and Nutrition Probiotics and prebiotics in pediatrics Pediatrics, 126 (2010), pp. 1217-1231 http://dx.doi.org/10.1542/peds.2010-2548
Medline
15 P.S. Gavilanes,H.A. Manjarrez,A. Cravioto
Inmunoproteccion por leche humana
Rev Mex Pediatr, 69 (2002), pp. 111-119
16 K.M. Hunt,J.A. Foster,L.J. Forney,U.M. Schütte,D.L. Beck,Z. Abdo
Characterization of the diversity and temporal stability of bacterial communities in human milk
PLoS One, 6 (2011), http://dx.doi.org/10.1371/journal.pone.0028413
Medline
17 C.W. Binns,M.K. Lee
Exclusive breastfeeding for six months: the WHO six months recommendation in the Asia Pacific Region
Asia Pac J Clin Nutr, 23 (2014), pp. 344-350
Medline
18 Lodesani G. Programa Mundial de Alimentos. Luchando contra el hambre en el mundo. Los primeros mil dias [en línea]. 2012 04 Oct [consultado 27 Dic 2014]. Disponible en: http://es.wfp.org/noticias/comunicado/los-primeros-mil-di.
19 E.L. Prado,K.G. Dewey
Nutrition and brain development in early life
Nutr Rev, 72 (2014), pp. 267-284 http://dx.doi.org/10.1111/nure.12102
Medline
20 C. Victora
[The thousand days opportunity for nutritional interventions: from conception to two years of life]
Arch Argent Pediatr, 110 (2012), pp. 311-317 http://dx.doi.org/10.5546/aap.2012.318
Medline
21 H. Bergmann,J.M. Rodríguez,S. Salminen,H. Szajewska
Probiotics in human milk and probiotic supplementation in infant nutrition: a workshop report
Br J Nutr, 112 (2014), pp. 1119-1128 http://dx.doi.org/10.1017/S0007114514001949
Medline
22 S. Khanna,P.K. Tosh
A clinician's primer on the role of the microbiome in human health and disease
Mayo Clin Proc, 89 (2014), pp. 107-114 http://dx.doi.org/10.1016/j.mayocp.2013.10.011
Medline
23 C. Urbaniak,J. Cummins,M. Brackstone,J.M. Macklaim,G.B. Gloor,C.K. Baban
Microbiota of human breast tissue
Appl Environ Microbiol, 80 (2014;), pp. 3007-3014 http://dx.doi.org/10.1128/AEM.00242-14
Medline
24 M. Olivares,M.P. Díaz-Ropero,R. Martín,J.M. Rodríguez,J. Xaus
Antimicrobial potential of four Lactobacillus strains isolated from breast milk
J Appl Microbiol, 101 (2006), pp. 72-79 http://dx.doi.org/10.1111/j.1365-2672.2006.02981.x
Medline
25 L. Morelli
Postnatal development of intestinal microflora as influenced by infant nutrition
J Nut, 138 (2008;), pp. 5S-1791S
26 M.W. Groer,A.A. Luciano,L.J. Dishaw,T.L. Ashmeade,E. Miller,J.A. Gilbert
Development of the preterm infant gut microbiome: a research priority
Microbiome, 2 (2014), pp. 38 http://dx.doi.org/10.1186/2049-2618-2-38
Medline
27 L. Fernández,S. Langa,V. Martín,A. Maldonado,E. Jiménez,R. Martín
The human milk microbiota: origin and potential roles in health and disease
Pharmacol Res, 69 (2013), pp. 1-10 http://dx.doi.org/10.1016/j.phrs.2012.09.001
Medline
28 F. Lara-Villoslada,M. Olivares,S. Sierra,J.M. Rodríguez,J. Boza,J. Xaus
Beneficial effects of probiotic bacteria isolated from breast milk
Br J Nutr, 98 (2007), pp. S96-S100 http://dx.doi.org/10.1017/S0007114507832910
Medline
29 A. Donnet-Hughes,P.F. Perez,J. Doré,M. Leclerc,F. Levenez,J. Benyacoub
Potential role of the intestinal microbiota of the mother in neonatal immune education
Proc Nutr Soc, 69 (2010), pp. 407-415 http://dx.doi.org/10.1017/S0029665110001898
Medline
30 E.W. Rogier,A.L. Frantz,M.E. Bruno,L. Wedlund,D.A. Cohen,A.J. Stromberg
Lessons from mother: long-term impact of antibodies in breast milk on the gut microbiota and intestinal immune system of breastfed offspring
Gut Microbes, 5 (2014), pp. 663-668 http://dx.doi.org/10.4161/19490976.2014.969984
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