¿Is COVID-19 a disease that affects the bone marrow? Experience in healthy donors of hematopoietic cells in a transplant center

Main Article Content

Sara Isabel Noreña Gomez
Angie Carolina Morales Suárez
Ángela Maria Tirado Giraldo
Andres Felipe Escobar González

Abstract

Objective: to write and analyze the effect of SARS-CoV-2 virus infection on cell mobilization in hematopoietic stem cell donors who attended the hematopoietic stem cell transplant unit of a highly complex medical institution in Medellín, Colombia. Methods: an analytical retrospective cross-sectional study based on medical records of patients undergoing bone marrow transplantation between March 2020 and March 2021. Results: of 64 hematopoietic cell donors and recipients, 22.2 % of recipients with a positive history of donor infection had granulocyte engraftment failure compared with 9.1 % of recipients without this history; there was no difference in mortality rate. The median number of CD34 cells mobilized in the donor population with a history of infection was 5 437 965 [IQR 5 070 714 – 7 215 985], similar to donors without a history (Median of 5 976 773 [IQR 5 046 689 – 7 276 463]) without finding differences (p=0.28). Conclusions: It is not possible to determine that SARS-CoV-2 infection generates changes in cells that are mobilized from an otherwise healthy hematopoietic stem cell donor; based on the performed statistical analysis, we do not believe that the data will change if the study population is expanded, although more prospective studies are required in the future.

Downloads

Download data is not yet available.

Article Details

How to Cite
Noreña Gomez, S. I., Morales Suárez, A. C., Tirado Giraldo , Ángela M., & Escobar González, A. F. (2023). ¿Is COVID-19 a disease that affects the bone marrow? Experience in healthy donors of hematopoietic cells in a transplant center. Pediatría, 55(4), 176–180. https://doi.org/10.14295/rp.v55i4.399
Section
Originals

References

Wiggill TM, Mayne ES, Vaughan JL, Louw S. Overview of the Haematological Effects of COVID-19 Infection Adv Exp Med Biol. 2021;1321:163-172. DOI: https://doi.org/10.1007/978-3-030-59261-5_14

Yu F, Jia R, Tang Y, Liu J, Wei B. SARS-CoV-2 infection and stem cells: Interaction and intervention. Stem Cell Res. 2020;46:101859. DOI: https://doi.org/10.1016/j.scr.2020.101859

Pascutti MF, Erkelens MN, Nolte MA. Impact of Viral Infections on Hematopoiesis: From Beneficial to Detrimental Effects on Bone Marrow Output. Front Immunol Front Immunol. 2016;16;7:364 DOI: https://doi.org/10.3389/fimmu.2016.00364

Debuc B, Smadja DM. Is COVID-19 a New Hematologic Disease? Stem Cell Rev Rep. 2021;17(1):4-8. DOI: https://doi.org/10.1007/s12015-020-09987-4

Domínguez-Rojas J, Campano W, Tasayco J, Siu-Lam A, Ortega-Ocas C, Atamari-Anahui N. Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: a Peruvian case report. Bol Méd Hosp Infant México. 2022;79(2):7012. DOI: https://doi.org/10.24875/BMHIM.21000061

Terpos E, Ntanasis‐Stathopoulos I, Elalamy I, Kastritis E, Sergentanis TN, Politou M, et al. Hematological findings and complications of COVID ‐19. Am J Hematol. 2020;95(7):834-47. DOI: https://doi.org/10.1002/ajh.25829

Lazarian G, Quinquenel A, Bellal M, Siavellis J, Jacquy C, Re D, et al. Autoimmune haemolytic anaemia associated with COVID‐19 infection. Br J Haematol. 2020;190(1):29-31. DOI: https://doi.org/10.1111/bjh.16794

Rosenzweig JD, McThenia SS, Kaicker S. SARS‐CoV‐2 infection in two pediatric patients with immune cytopenias: A single institution experience during the pandemic. Pediatr Blood Cancer [Internet]. Pediatr Blood Cancer. 2020;67(9):e28503. DOI: https://doi.org/10.1002/pbc.28503

Hernandez JM, Quarles R, Lakshmi S, Casanas B, Eatrides J, McCoy E, et al. Pancytopenia and Profound Neutropenia as a Sequela of Severe SARS-CoV-2 Infection (COVID-19) With Concern for Bone Marrow Involvement. Open Forum Infect Dis. 2021;8(2):ofab017. DOI: https://doi.org/10.1093/ofid/ofab017

Sharma A, Bhatt NS, St Martin A, Abid MB, Bloomquist J, Chemaly RF, et al. Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study. Lancet Haematol. 2021;8(3):e185-93. DOI: https://doi.org/10.1016/S2352-3026(20)30429-4

Ljungman P, de la Camara R, Mikulska M, Tridello G, Aguado B, Zahrani MA, et al. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey. Leukemia. 2021;35(10):2885-94. DOI: https://doi.org/10.1038/s41375-021-01302-5

Daudt LE, Corso MCM, Kerbauy MN, de Assis LH dos S, Rechenmacher C, Colturato I, et al. COVID-19 in HSCT recipients: a collaborative study of the Brazilian Society of Marrow Transplantation (SBTMO). Bone Marrow Transplant. 2022;57(3):453-9. DOI: https://doi.org/10.1038/s41409-021-01561-x

Most read articles by the same author(s)

Similar Articles

1 2 3 4 5 6 7 8 > >> 

You may also start an advanced similarity search for this article.